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KMID : 0363620080290010067
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Journal of Korean Oriental Medicine
2008 Volume.29 No. 1 p.67 ~ p.84
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Effect of Jasinwhalhyul-tang on MRL/MpJ-Ipr/Ipr Mouse Model with Systemic Lupus Erythematosus
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Choi Hoon-Seob
Cho Chung-Sik
Kim Cheol-Jung
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Abstract
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Objective: The main purpose of this study was to evaluate the effect of Jasinwhalhyul-tang (Zishenhuoxue-tang,
JWT) on MRL/MpJ-Ipr/Ipr mouse model with systemic lupus erythematosus.
Methods: The effect of JWT on MRL/MpJ-Ipr/Ipr mice that have autoimmune disease similar to SLE in humans
was evaluated after JWT per oral in the present study. Mice were administered with Jasinwhalhyul-tang (Zishenhuoxue-
tang, JWT) (80 or 400mg/kg) or distilled water for control group from experimental week 10 for 22 weeks.
Results: The amount of erythematosus skin lesion and proteinuria were significantly decreased. The size and weight of cervical lymph nodes and spleen were significantly reduced. The ratio between activated CD3+CD69+ T-cells and undifferentiated CD3+CD4-CD8- T-cells in lymph nodes, spleen and kidney was effectively reduced. The gene
expression of TGF-β in spleen and kidney was increased. The amount of anti-dsDNA IgG in blood was decreased. The gene expression of TGF-β in normal mouse spleen cells was increased depending on concentration by treatment of with T cell stimulating agent. In the histological examination of skin and kidney, the amount of infiltration of immune cells involved in the inflammatory response was decreased.
Conclusions: According to the above results, JWT should be considered as an applicable therapeutic agent to SLE in clinical practice. Further research is required to investigate other efficacies of JWT on SLE.
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KEYWORD
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SLE, Jasinwhalhyul-tang (Zishenhuoxue-tang, JWT), MRL/MpJ-Ipr/Ipr mouse model
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